Proton pump inhibitors, or PPIs, are a class of drugs that treat acid reflux and peptic ulcers. The three most commonly prescribed PPIs are omeprazole, pantoprazole and esomeprazole. In recent years, some studies reported that PPIs increase risk for dementia, including Alzheimer’s disease. We hear patients asking questions about this issue, so I’d like to clarify what we currently know about this risk.